[Regulation of Retrotransposons in Drosophila melanogaster Somatic Tissues].

Regulation of retrotransposon activity in somatic tissues is a complex mechanism that has still not been studied in detail. It is strongly believed that siRNA interference is main mechanism of retrotransposon activity regulation outside the gonads, but recently was demonstrated that piRNA interference participates in retrotransposon repression during somatic tissue development. In this work, using RT-PCR, we demonstrated that during ontogenesis piRNA interference determinates retrotransposon expression level on imago stage and retrotransposons demonstrate tissue-specific expression.

Knockout of genes significantly affects locomotion speed and gene expression in leg skeletal muscles of .

The functions of the heat shock protein 70 () genes were studied using a line of with a knockout of 6 of these genes out of 13. Namely, the effect of knockout of genes on negative geotaxis climbing (locomotor) speed and the ability to adapt to climbing training (0.5-1.

The Lifespan of Depends on the Function of the Gene, a Domesticated Gene of Drosophila LTR Retrotransposons.

(1) Background: The gene in 's genome originated from the molecular domestication of retrotransposons and retroviruses' gene. In all species, the Gagr protein homologs exhibit a conserved structure, indicative of a vital role. Previous studies have suggested a potential link between the gene function and stress responses.

Stress Induced Activation of LTR Retrotransposons in the Genome.

Retrotransposons with long terminal repeats (LTR retrotransposons) are widespread in all groups of eukaryotes and are often both the cause of new mutations and the source of new sequences. Apart from their high activity in generative and differentiation-stage tissues, LTR retrotransposons also become more active in response to different stressors. The precise causes of LTR retrotransposons' activation in response to stress, however, have not yet been thoroughly investigated.