Publications by authors named "I V Kudryavtsev"
Article Synopsis
- * Diagnosing sarcoidosis is challenging due to its diverse presentations and the absence of specific biomarkers, leading to complications in understanding its course and treatment.
- * The review emphasizes the need for new diagnostic criteria and recommends developing a reliable immunological or imaging marker to improve diagnosis and prognosis for patients with chronic sarcoidosis.
Coronary artery bypass grafting (CABG) using cardiopulmonary bypass (CPB) causes a systemic inflammatory response that can worsen patient outcomes. Off-pump surgery has been associated with a reduced inflammatory response. The precise mechanisms and the role of extracellular vesicles (EVs) in this context are not fully understood.
View Article and Find Full Text PDFHybrid nano- and microparticles based on metal ion crosslinked biopolymers are promising carriers for the development of drug delivery systems with improved biopharmaceutical properties. In this work, dexamethasone phosphate-containing particles based on chondroitin sulfate and chitosan or diethylaminoethyl chitosan additionally crosslinked with Zn were prepared. Depending on the polycation/polyanion ratio in the system, anionic and cationic polyelectrolyte complexes (PECs) were obtained.
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- The study focuses on the role of T regulatory cells (Tregs) in managing immune responses during COVID-19, highlighting their importance in controlling inflammation and immune balance throughout infection and recovery.
- Researchers analyzed Treg subpopulations in COVID-19 patients at various stages—acute infection, early recovery, and long-term convalescence—finding a significant decrease in Tregs during the acute phase, which correlated with increased inflammation and disease severity.
- After recovery, Treg levels gradually improved but did not fully return to those of healthy individuals one year later, indicating persistent immune changes, particularly in the expression of purinergic markers like CD39 and CD73.
Background: Influenza and SARS-CoV-2 viruses are two highly variable pathogens. We have developed a candidate bivalent live vaccine based on the strain of licensed A/Leningrad/17-based cold-adapted live attenuated influenza vaccine (LAIV) of H3N2 subtype, which expressed SARS-CoV-2 immunogenic T-cell epitopes. A cassette encoding fragments of S and N proteins of SARS-CoV-2 was inserted into the influenza NA gene using the P2A autocleavage site.
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