[Laboratory diagnosis of disseminated intravascular blood coagulation syndrome in patients with rheumatoid arthritis].

DIC-syndrome frequently associated with anemia is one of rheumatoid arthritis complications which runs latently in the presence of hypercoagulation and low fibrinolytic activity. The development of DIC syndrome in the above patients correlates with the process activity, pattern of the disease, is independent of rheumatoid arthritis stage and duration, the patients' age, immunological and serological characteristics. Concentrations of circulating immune complexes and DIC-syndrome are related in rheumatoid arthritis patients with anemia.

[Plasmapheresis in the combined treatment of rheumatoid arthritis, complicated with anemia and blood coagulation disorders].

Time course of changes in hemostasis were investigated in 68 rheumatoid arthritis (RA) patients. DIC syndrome and anemia were recorded in 23 and 20 patients, respectively. Three RA sufferers were free of anemia.

[Effect of plasmapheresis with substitution by dextran solutions on hemostatic parameters in patients with ischemic heart disease].

Plasmapheresis on a continuous blood flow fractionator to remove 1,200-2,000 ml plasma and substitute for the same values of dextran solutions was employed in the multi-modality treatment of 25 patients with Functional Classes II-IV exertional angina and myocardial infarction. Plasma and thrombocyte hemostatic parameters were examined just before and 24 and 48 hours after plasmapheresis. The analysis of the baseline data revealed that hemostatic changes were directly related to the severity of a disease in the patients and there was a correlation between the increased platelet aggregability and the elevated levels of fibrin-monomeric complexes.

[Therapeutic plasmapheresis in chronic diffuse diseases of the liver].

The results of the clinico-laboratory investigations conducted in time course have evidenced a high therapeutic effectiveness of plasmapheresis in the complex treatment of patients with chronic active hepatitis and biliary cirrhosis of the liver. Plasmapheresis use has been validated and indicated in patients with a manifest biliary component, a high degree of the process activity and ineffectiveness or low effectiveness of the previous treatment.

[Intensive transfusion-infusion therapy of patients with cirrhosis of the liver].

Optimum programs have been developed for the differential intensive transfusion-infusion therapy of patients with cirrhosis of the liver, based on the characteristics of the clinical course of the disease and the directed action of varying current solutions. Overtime clinical investigations were conducted in 296 patients with cirrhosis of the liver. The results of the study have shown a favourable effect of the components, blood preparations and hemocorrectors on the clinical signs of the disease, on the function of the liver, kidneys, hemostasis system and microcirculation.