[Aging of the brain reward system].

This minireview is the first attempt to summarize the scarce data on the physiological changes that occur with aging in opioid, serotonergic, dopaminergic and other systems of the brain associated with the reward reactions.

[Clinical aspects of the using of clopheline in postoperative period in elderly patient with arterial hypertension].

The positive clinical effects of using of clopheline in postoperative period in elderly patent with arterial hypertension are presented in this article. Clopheline has the good hypotensive effects. This drug may be recommended for treatment the hypertensive postoperative reaction.

[S. P. Botkin--the founder of the domestic clinical gerontology].

The first in the world large-scale gerontology investigation where 2620 elderly patients were examined was carried out by guidance professor S. P. Botkin in St.

[Pineal gland and extrapineal melatonin in visceral organs during natural human aging].

In order to define the functional morphology of the pineal gland (epiphysis) and to reveal extrapineal sources of melatonin (MT) during human aging, biopsy samples obtained from 175 male persons aged 16 to 84 were examined. The dynamics of MT-containing cells in the stomach, intestine, bronchi, prostate and the non-endocrinal cells of the adrenals were described.

[Extrapineal melatonin in processes of accelerated and premature aging in rats].

In order to reveal the participation of extrapineal melatonin in ageing processes, Wistar rats were (a) exposed to small doses of gamma irradiation and (b) subjected to pinealectomy. It was showed that during a radiation-induced aging simulation occurs a manifest hypoplasia of MT-responder cells in the mucosa of the duodenum, and the number of mast cells is reduced by ten times. During pinealectomy the number of MT-positive enterochromaffin cells increases.