The effect of lactoferin on the free radical and cytokine status of cornea in the experimental thermal burn.

The free radical and cytokine statuses of the cornea during its thermal burn and the possibility of its correction by lactoferrin have been studied in Soviet Chinchilla rabbits. The development of a corneal thermal burn was accompanied by the development of oxidative stress (increased levels of TBA-reactive substances and carbonyl derivatives of proteins, decreased activity of SOD and GPx enzymes) and a pronounced inflammatory reaction with increased levels of TNF-1α, IL-10, TGF-1β. The use of lactoferrin had a pronounced therapeutic effect, which was manifested by accelerated healing, prevention of the development of complications (corneal perforations), a decrease in the severity of oxidative stress, an increase in the concentrations of TNF-1α (in the early stages), IL-10 (in the later stages), TGF-1β (throughout the experiment).

[Somatic polyploidy in neurons of the gastropod mollusca. III. Mitosis and endomitosis in the postnatal development of neurons in the Succinea snail central nervous system].

General morphology of chromatin, the number of chromosomes and chromocenters in normal condition and at the increase of bivalent cation (Ca2+, Mg2+) concentration were studied with the purpose to reveal mechanisms of polyploidization of neuron nuclei in the snail Succinea lauta (Gastropoda, Pulmonata). The morphology of nuclei was studied on squashed preparations. Normal diploid mitoses are described in the cerebral ganglia.

[Somatic polyploidy in neurons of the gastropod molluscs. II. Dynamics of DNA synthesis in the process of postnatal growth of CNS neurons in Succineid snail].

A study was made of the age dynamics of polyploidization and dynamics of DNA synthesis in neuron cell nuclei during the postnatal growth of the gastropod pulmonate snail Succinea lauta. According to cytophotometrical results, the degree of polyploidization in neuron nuclei increases from young to adult individuals, varying from 2c to 16,384c. In the visceral complex, the maximum and medium ploidy values of the neuron nuclei are higher by almost 4-8 times than those in cerebral and pedal ganglia.

[Somatic polyploidy in neurons from gastropod mollusks. I. Morphological characteristics of ganglia and neurons in the CNS of the snail Succinea lauta].

A study was made of general anatomy and histological organization of the central nervous system in Succinea lauta, a gastropod pulmonate snail. Neurons grow by means of polyploidy during the postnatal succineid ontogeny. In the adult individuals diameters of perikaria of large neurons increase 2.