[Glycosylation products in the early diagnosis and prognostic evaluation of carbohydrate metabolism disorders].

HbAIc and FA were investigated as markers in the diagnosis of early carbohydrate metabolic derangements. A group with normal TSH and a high concentration for glycosylation products was singled out. Carbohydrate metabolic derangements in 89 per cent showed a tendency to progression.

[Free fatty acid spectrum and rheological properties of erythrocytes in people with disturbed glucose tolerance and in patients with diabetes mellitus].

The paper is devoted to a study of mechanisms of deterioration of blood rheological properties in disturbed carbohydrate metabolism in 17 patients with disorders in GTT and in 83 patients with diabetes mellitus (DM). The level of lipids, the spectrum of fatty acids (SFA) were determined in the blood plasma using gas chromatography by an original method, proposed by the authors for assessment of the rheological properties of erythrocytes (rotation viscosimetry of erythrocyte suspension in standard hematocrit of 45%). The concentrations of saturated and polyunsaturated acids in the blood plasma of persons with disturbed GTT and DM were increased, and the concentration of linoleic acid was lowered.

[Glycosylated proteins and the rheological properties of the erythrocytes in carbohydrate metabolic disorders].

The level of glycosylated hemoglobin (Hb AIc), the concentration of glycosylated proteins in red blood cell membranes (GPCM), and fructosamine were measured in patients with different carbohydrate metabolism abnormalities (glucose tolerance test disorders, insulin-dependent diabetes mellitus/IDDM/). The "pyrene" probe was used to examine rheological disorders in different shift rates and microviscosity of red blood cell membranes. Close correlations were established between glycosylated proteins and microviscosity as well as between GPCM and viscosity of red blood cell suspension.