Publications by authors named "I V Ilyina"
Article Synopsis
- * This study explores reactions between salicylic aldehydes and a specific monoterpene derivative, resulting in various chiral polycyclic products, with some being novel ring structures.
- * The results indicate that the type of acid catalyst used and the reaction conditions significantly influence the product outcomes, and the study includes detailed mechanistic insights supported by experimental and computational methods.
The yeasts Cryptococcus albidus (Naganishia albida) usually occur on natural substrates and rarely are the etiological factor of different mycoses. More than a half of mycosis cases described in the literature were reported during the period from 2004 to 2021. In this regard, evaluation of yeast sensitivity to antimycotic drugs is as important as their identification.
View Article and Find Full Text PDFThe ability of actinobacteria of the genus to biotransform the monoterpenoid (-)-isopulegol has been established for the first time. . strain IEGM 1362 was selected as a bacterium capable of metabolizing (-)-isopulegol to form new, previously unknown, 10-hydroxy () and 10-carboxy () derivatives, which may presumably have antitumor activity and act as respiratory stimulants and cancer prevention agents.
View Article and Find Full Text PDFWe synthesized fluoro- and hydroxy-containing octahydro-2H-chromenes by the Prins reaction starting from a monoterpenoid (-)-isopulegol and a wide range of aromatic aldehydes in the presence of the BF∙EtO/HO system acting as both an acid catalyst and a fluorine source. Activity of the produced compounds against the influenza A/Puerto Rico/8/34 (H1N1) virus was studied. The highest activity was demonstrated by fluoro- (11i) and hydroxy-containing (10i) derivatives of 2,4,6-trimethoxybenzaldehyde.
View Article and Find Full Text PDFA set of (-)-isopulegol derived octahydro-2H-chromen-4-ols was synthesized and evaluated in vitro for antiviral activity against panel of reference influenza virus strains differing in subtype, origin (human or avian) and drug resistance. Compound (4R)-11a produced via one-pot synthesis by interaction between (-)-isopulegol and acetone was found to exhibit an outstanding activity against a number of H1N1 and H2N2 influenza virus strains with selectivity index more than 1500. (4R)-11a was shown to be most potent at early stages of viral cycle.
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