[Studies of red blood cells biochemistry and erythropoiesis intensity in humans during the 520-day isolation study].

Erythrocyte metabolism and erythropoiesis intensity were investigated in the humans subjects (6 males, 25 to 37 yrs. of age) volunteered for experimental simulation of such factors in a mission to Mars as very long duration (520-d) of isolation and confinement, autonomy, delayed communication, emergencies, and limited consumable resources. Venous blood and extracted erythrocytes were analyzed in the baseline data collection period (2 wks.

[Examination of the morphofunctional properties of red blood cells of humans in 5-day dry immersioin].

Blood of six normal male volunteers sampled before, immediately after and in 7 days since 5-d dry immersion was analyzed for morphological parameters, erythrocyte metabolism, lipids and phospholipids levels. The experimental exposure was shown to increase the erythrocyte count. Also, upward trends were displayed by hemoglobin and PCV on the first day after the experiment; a significant decrease in adenosine triphosphate and low level of reduced glutathione could be an outcome of enhanced oxidation in cell due to, maybe, LPO activation.

[Studies of the blood antioxidant system and oxygen-transporting properties of human erythrocytes during 105-day isolation].

Effects of strict 105-d isolation on blood antioxidant status, erythrocyte membrane processes and oxygen-binding properties of hemoglobin were studied in 6 male volunteers (25 to 40 y.o.) in ground-based simulation of a mission to Mars (experiment Mars-105).

[Investigations of the morphofunctional properties of red blood in human subjects during 9-day exposure in oxyargon medium with various oxygen content].

Biochemical investigations of red blood and oxygen transportation by erythrocyte hemoglobin were performed in volunteered for chamber experiments (0.14 MPa) with normal and hypoxic oxyargon medium (O2-Ar). Erythrocyte metabolism, lipid and phospholipids spectra, and effectiveness of oxygen release and retention by hemoglobin were studied in the baseline data collection period, on day 6 in hyperbaric and normoxic O2-Ar medium (13.

[Red blood of cosmonauts on missions aboard the International Space Station (ISS)].

Morphobiochemical investigations of red blood (space experiment Hematologiya) involved the ISS Russian crew members (increments 6-12). Blood samples were drawn on L-30, at the beginning (FD 6-10) and end (FD 160-190) of orbital flight, shortly after landing (R+0), and on R+7 and R+15. Results of the investigations of red blood metabolism and cell membrane showed that long-duration space flight reduces the hemoglobin level in consequence of, probably, intensive erythropoiesis and premature partial elimination of degraded (possibly old) erythrocytes from circulating blood.