[Investigation of bacterial translocation regularities in diffuse peritonitis using labeled radionuclide colibacillus].

The investigation of the regularities of translocation of opportunistic pathogenic microflora from the small intestine lumen and abdominal cavity in diffuse peritonitis using labeled radionuclide colibacillus has shown that in normal condition the intestinal barrier is not permeable for bacteria. Under conditions of diffuse peritonitis the bacterial translocation and peritoneal resorption are developing since the first minutes of the disease. During the development of the pathological process the priority of the foci of bacterial toxemia is changed from peritoneal to intestinal.

[Pathophysiological mechanisms of bacterial endotoxicosis in disseminated peritonitis].

Using methods of nuclear medicine in experiment, we studied pathophysiologic mechanisms of bacteriemia in disseminated peritonitis in various laboratory animals. The results give grounds to consider regularities revealed to be universal.

The 262T>C promoter polymorphism of the catalase gene is associated with diabetic neuropathy in type 1 diabetic Russian patients.

Objective: Oxidative stress plays an important role in the development of diabetic neuropathy (DN). Antioxidant enzymes reduce enhanced oxidative stress in the peripheral nerve. Genetic variations within the antioxidant genes therefore could be implicated in the pathogenesis of DN.

[Polymorphic markers of the NO synthase genes and genetic predisposition to diabetic polyneuropathy in patients with type 1 diabetes mellitus].

The allele and genotype frequencies of polymorphic markers of NOS1, NOS2 and NOS3 genes, encoding three types of NO synthases, were compared in type 1 diabetes patients with and without diabetic polyneuropathty. 180 type 1 diabetes patients (T1DM) of Russian or Eastern Slavonic origin, living in Moscow city, were divided into two groups using non-overlapping (polar) phenotypes. 86 patients had overt DPN and T1DM duration in this group was less than 5 years (DPN+ group) and 94 patients had no clinical DPN and T1DM duration was more than 10 years (DPN- group).