Pasteurella multocida Spondylodiscitis in an Immunocompetent Patient.

We present the case of an 82-year-old woman, previously independent in activities of daily living, who developed fever, myalgias, and headache over one week. Two weeks earlier, she had been treated with antibiotics for a lower respiratory tract infection. The patient had no history of immunosuppression and was a pet owner.

Effects of a Session of Exergames and Traditional Games on Inhibitory Control in Children With Autism Spectrum Disorder: Randomized Controlled Crossover Trial.

Background: Autism spectrum disorder (ASD) is characterized by deficits in executive functions, such as inhibitory control, which affect behavior and social adaptation. Although physical activity-based interventions, such as exergames, have shown potential to improve these functions, their comparative effects with active traditional games remain underexplored, particularly regarding inhibitory control in children with ASD.

Objective: We aim to analyze the effects of a session of exergames and active traditional games on inhibitory control in children with ASD.

Bispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concern.

The ongoing emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) that reduce the effectiveness of antibody therapeutics necessitates development of next-generation antibody modalities that are resilient to viral evolution. Here, we characterized amino-terminal domain (NTD)- and receptor binding domain (RBD)-specific monoclonal antibodies previously isolated from coronavirus disease 2019 (COVID-19) convalescent donors for their activity against emergent SARS-CoV-2 VOCs. Among these, the NTD-specific antibody C1596 displayed the greatest breadth of binding to VOCs, with cryo-electron microscopy structural analysis revealing recognition of a distinct NTD epitope outside of the site i antigenic supersite.

Antibiotic resistance and biofilm formation in Klebsiella spp. isolates from Intensive Care Units in the Brazilian Amazon.

Klebsiella spp. is an opportunistic pathogen which poses a significant threat to public health, especially due to antimicrobial resistance and biofilm formation. This study aimed to determine the antibiotic resistance profile, biofilm formation and β-lactamases production in Klebsiella spp.

Initial adiposity is associated with body composition changes in response to diet-induced weight loss in normal-weight healthy individuals: The first results of the NUTRILEX study.

While a significant number of normal-weight individuals are engaged in dieting practices, there is a need to better characterize the composition of weight change during and after weight loss (WL) intervention in this population. The study aimed to examine body composition in response to diet-induced WL and 4-month follow-up in normal-weight adults. Thirty-five participants (23 ± 4 y, 24 females) joined the laboratory to measure body weight (BW) and body composition using Dual-energy X-ray absorptiometry on 5 occasions: baseline (T0), 3 % WL (T1, n = 32), 6 % WL (T2, n = 18), 1-month follow-up (T3, n = 18), 4-month follow-up (T4, n = 16).