Publications by authors named "I V Chistyakov"
The escalating resistance of uropathogens in pediatric febrile urinary tract infection (F-UTI) is a global concern. This study examined changing trends in F-UTI epidemiology and resistance patterns among Israeli pediatric inpatients over a decade. Demographic, clinical, and laboratory data for children between 3 months and 18 years old with febrile UTI from 2010 to 2021 were retrieved from electronic medical records.
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- Single-agent immune checkpoint inhibitors (ICIs) are commonly used for treating metastatic non-small cell lung cancer (NSCLC) after chemotherapy, but only some patients respond effectively.
- A study involving 181 patients identified factors like poor performance status, never-smoking history, and a high neutrophil-to-lymphocyte ratio (NLR) that were linked to shorter survival and worse outcomes.
- Patients with favorable conditions (NLR <4.3, good performance status, and past smoking) had the best responses to ICIs, while those with poor indicators had significantly worse results, demonstrating the potential for personalized treatment predictions.
Objective: Determining infection etiology can be difficult because viral and bacterial diseases often manifest similarly. A host protein test that computationally integrates the circulating levels of TNF-related apoptosis-induced ligand, interferon γ-induced protein-10, and C-reactive protein to differentiate between bacterial and viral infection (called MMBV) demonstrated high performance in multiple prospective clinical validation studies. Here, MMBV's diagnostic accuracy is evaluated in febrile children for whom physicians were uncertain about etiology when applied at the physician's discretion.
View Article and Find Full Text PDFMedication overuse headaches are a frequent phenomenon observed in individuals suffering from chronic headaches. It arises due to the excessive consumption of pain-relief medications, resulting in the escalation and continuous persistence of headache symptoms. Nevertheless, the prevalence and distinctive characteristics of medication overuse headaches in the pediatric population have not been comprehensively explored.
View Article and Find Full Text PDFObjectives: Vaccination is the primary intervention to prevent influenza infection, yet vaccine uptake remains low among children and other at-risk patients. The aim of the study is to investigate the impact of a paediatric hospital visit with laboratory-confirmed influenza on the influenza vaccination behaviour of participants and their family members in the subsequent influenza season.
Methods: This study compared the influenza vaccination coverage for participants < 18 years of age with a clinical suspicion of influenza in 2017-2018 during a hospital visit, in two subsequent influenza seasons.