[Neurotensin NT (8- 13) dipeptide analog dilept increases the pain threshold and decreases the severity of morphine withdrawal syndrome in rats].

The pain threshold effects of a neurotensin NT (8 - 13) dipeptide analog (dilept), morphine, and their combination have been studied using the tail flick test in rats. The animals of another experimental group were administered with morphine in increasing doses (10 - 20 mg/kg, i.p.

[Afobazole decreases severity of morphine withdrawal syndrome: experimental evidence].

Effect of afobazole upon morphine dependency has been studied in rats upon the administration of incremental doses of morphine (10-20 mg/kg, i.p.) for 5 days.

[Impact of a magnetic field on blood separation kinetics in patients with joint diseases].

The paper gives the results of experiments on phase separation of blood in the constant magnetic field that allows the structure of blood to be regulated, without changing its cellular and chemical composition. Blood deposition kinetic relationships were obtained for patients with joint diseases of various etiology (osteoarthritis, osteoarthrosis deformans, endoprosthesis instability, contusions, and joint wounds). They correlate with the severity of an inflammatory process in the joint and its adjacent tissues, with a patient's resistance to the development of pathology, and with red blood cell mobility in the biophysical field of a living organism.

[Molecular mass distribution of proteins in serum and synovial fluid].

The Laemmli polyacrylamide gel protein electrophoresis method was used to assess the protein molecular mass distribution in the serum and synovial fluid from apparently healthy individuals and patients with knee osteoarthritis of various etiologies. The development of inflammatory complications in joint diseases was shown to be identified on the protein separation spectra as a rise in the synovial fluid concentration of protein fractions with the extremely low molecular mass (to 20 kD). The protein molecular mass distribution in the sera in all the groups and that in the synovial fluid from the apparently healthy joints were virtually equal.

[Infrared spectroscopy of synovial fluid and serum from patients with joint diseases].

The infrared spectra of synovial fluid and serum from the same patient were comparatively analyzed. The coordination bond variations in the complex protein-polysaccharide compounds of synovial fluid were shown to correspond to the range of frequencies of 3000-3500 cm(-1) and those of valence bonds in its individual components were in the range of 800-1700 cm(-1). It was established that a reduction in the peak area of 3300 cm(-1) may be an additional indicator in the diagnosis of osteoarthritis.