Analysis of T-cell and Humoral Immune Response to SARS-CoV-2 Antigens in Rituximab-Treated Patients with Rheumatoid Arthritis Vaccinated with Combined Vector Vaccine Gam-COVID-Vac.

The COVID-19 pandemic has brought significant changes in managing of patients with rheumatoid arthritis. Rituximab-treated patients were more susceptible to severe infection. This required a "switch" to another genetically engineered drug in the patients with high risk of adverse COVID-19.

Feasibility of spirography features for objective assessment of motor function in Parkinson's disease.

Objective: Parkinson's disease (PD) is currently incurable, however proper treatment can ease the symptoms and significantly improve the quality of life of patients. Since PD is a chronic disease, its efficient monitoring and management is very important. The objective of this paper was to investigate the feasibility of using the features and methodology of a spirography application, originally designed to detect early Parkinson's disease (PD) motoric symptoms, for automatically assessing motor symptoms of advanced PD patients experiencing motor fluctuations.

Polymetallic complexes linked to a single-frame ligand: cooperative effects in catalysis.

In an eco-friendly development, catalysis represents the key approach for converting raw materials into valuable products, particularly convenient for multi-step transformations. Mimicking Nature seems the smartest way to design poly-functional assemblies leading to the design of "synergic" catalysts. This perspective focuses on the advances in the conception of polymetallic catalysts bonded to a single ligand frame.

9,10-Dihydroanthracenyl structures: original ligands for the synthesis of polymetallic complexes through selective π-coordination.

N-Phenylsuccinimides and the corresponding pyrrolidines containing 9,10-dihydroanthracenyl skeletons were used for exploring their ability to coordinate RuCp(+) moieties through the aromatic rings. Electronic and steric tuning of ligands led to mono-, bi- and tri-metallic complexes. A full structural study was carried out in order to characterize the ruthenium organometallic compounds, proving the different coordination modes both in solution (NMR) and in solid state (X-ray diffraction).

(1S,8R,15S,19R)-17-Benzyl-17-aza-penta-cyclo-[6.6.5.0(2,7).0(9,14).0(15,19)]nona-deca-2(7),3,5,9(14),10,12-hexa-ene chloro-form monosolvate.

In the title compound, C(25)H(23)N·CHCl(3), the dihydro-anthracene unit is bent with a dihedral angle between the benzene rings of 57.82 (8)°. The N atom of the pyrrolidine heterocycle, which has an envelope conformation with the N atom as the flap, exhibits a pronounced pyramidalization [Σ(C-N-C) = 328.