Publications by authors named "I V Alekseenko"
It is established that BCG vaccination results in the development of both a specific immune response to mycobacterial infections and a nonspecific (heterologous) immune response, designated as trained immunity (TRIM), to other pathogens. We hypothesized that local BCG immunization may induce an early immune response in bone marrow and spleen innate immunity cells. The early transcriptomic response of various populations of innate immune cells, including monocytes, neutrophils, and natural killer (NK) cells, to BCG vaccination was examined.
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- - The study examines the potential role of lipids as biomarkers for diagnosing anxiety and depression, which are major contributors to mental health issues and disability, despite the lack of existing biochemical tests for these conditions.
- - Researchers analyzed blood plasma lipid levels in a group of 604 urban individuals and compared them to 32 patients with clinical depression, finding significant correlations between lipid levels and the severity of depressive symptoms.
- - The findings suggest that lipid alterations seen in clinically depressed patients can also be observed in the general population, leading to the creation of a predictive model with high accuracy for identifying individuals with severe depressive symptoms.
Article Synopsis
- Despite significant investment and effort over the past 52 years in the "War on Cancer," traditional treatment methods like chemotherapy and radiation have fallen short of expectations.
- A new approach proposes targeting cancer-stromal synapses, the connections between cancer cells and their surrounding microenvironment, which could lead to more effective treatment.
- This method aims to disrupt these synapses using targeted chemical agents, potentially enhancing treatment safety, precision, and reducing the likelihood of drug resistance.
Objectives: Current data suggests that Bacille Calmette-Guerin (BCG) vaccination contributes to nonspecific enhancement of resistance to various infections. Thus, BCG vaccination induces both specific immunity against mycobacteria and non-specific "trained immunity" against various pathogens. To understand the fundamental mechanisms of "trained" immunity, studies of transcriptome changes occurring during BCG vaccination in innate immunity cells, as well as in their precursors, are necessary.
View Article and Find Full Text PDFBackground: Immune checkpoint blockade (ICB) is rapidly becoming a standard of care in the treatment of many cancer types. However, the subset of patients who respond to this type of therapy is limited. Another way to promote antitumoral immunity is the use of immunostimulatory molecules, such as cytokines or T cell co-stimulators.
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