Thyroid Functions and Cognitive Decline in the Elderly.

Background The maintenance of cognitive health depends on thyroid hormones, and it is becoming more widely acknowledged that thyroid hormone issues may be a factor in cognitive decline in the aged. Objective This study aimed to investigate the association between thyroid hormone levels and cognitive decline among elderly individuals, considering the influence of age-related factors and comorbidities. Methodology Over the course of two years, 218 adults 60 years of age and older with clinically diagnosed hypothyroidism or subclinical thyroid disease were included in a prospective observational research.

Layer-dependent Schottky contact at TaX-BY (X = S, Se, Te; Y = P, As, Sb) van der Waals interfaces.

The mechanical, thermal and dynamical stabilities, electronic structure, contact type, and height of the barrier at the interface of TaX (X = S, Se, Te) and BY (Y = P, As, Sb) metal-semiconductor (MS) contact are investigated first principles calculations. Binding energies, mechanical properties, phonon spectra and molecular dynamics (AIMD) simulations confirm the stabilities of these systems. TaX-BY (X = S, Se, Te; Y = P, As, Sb) MS van der Waals heterostructures (vdWHs) are found to be metal with a Schottky contact at the interface.

The journey of antibody-drug conjugates for revolutionizing cancer therapy: A review.

Antibody-drug conjugates (ADCs) represent a powerful class of targeted cancer therapies that harness the specificity of monoclonal antibodies to deliver cytotoxic payloads directly to tumor cells, minimizing off-target effects. This review explores the advancements in ADC technologies, focusing on advancing next-generation ADCs with novel payloads, conjugation strategies, and enhanced pharmacokinetic profiles. In particular, we highlight innovative payloads, including microtubule inhibitors, spliceosome modulators, and RNA polymerase inhibitors, that offer new mechanisms of cytotoxicity beyond traditional apoptosis induction.

Antibacterial and Antibiofilm Potential of Chlorophyllin Against In Vitro and In Silico.

Background: is a leading causative agent of dental caries and exerts pathogenicity by forming biofilms. Dental caries continues to be a significant public health issue worldwide, affecting an estimated 2.5 billion people, showing a 14.