Publications by authors named "I Turel"
Article Synopsis
- - This study explored 12 new rhenium(I) complexes, focusing on their stability and behavior in aqueous solutions, particularly how they remain intact at various pH levels without losing their ligands.
- - The complexes demonstrated varied stability in biological environments such as cell culture media and real blood serum, showing changes in solubility and lipophilicity due to ligand substitution and hydrolysis over time.
- - While the halido complexes exhibited higher cytotoxic effects against certain cancer cells compared to their aqua counterparts, both showed no antibacterial properties but some moderate antiviral activity against Herpes simplex virus 2.
Article Synopsis
- The study compared the effects of thymoquinone (TQ), St. John wort (SJW), and silver sulfadiazine (AgSD) on wound healing in rats subjected to burns.
- Topical TQ significantly accelerated healing, enhanced granulation and vascularization, and improved antioxidant levels, while SJW showed some positive effects but was less effective in systemic application.
- AgSD reduced oxidative stress but negatively impacted the wound healing process, suggesting that TQ is the most effective treatment, SJW works better topically, and AgSD should be used with caution.
Nicotinic acetylcholine receptors (nAChRs) are expressed in excitable and non-excitable cells of the organism. Extensive studies suggest that nAChR ligands have therapeutic potential, notably for neurological and psychiatric disorders. Organometallic ruthenium complexes are known to inhibit several medically important enzymes such as cholinesterases.
View Article and Find Full Text PDFIn this paper, three different Zn(II) complexes with ()-2-(2-(1-(6-bromopyridin-2-yl)ethylidene)hydrazinyl)-,,-trimethyl-2-oxoethan-1-aminium chloride (HLCl) have been synthesized and characterized by single crystal X-ray diffraction, elemental analysis, IR and NMR spectroscopy. All complexes are mononuclear, with the ligand (L) coordinated in a deprotonated formally neutral zwitterionic form NNO donor set atoms. Complex 1 forms an octahedral geometry with the composition [ZnL](BF), while complexes 2 [ZnL(NCO)] and 3 [ZnL(N)] form penta-coordinated geometry.
View Article and Find Full Text PDFRecognizing that metal ions play an important role in modifying the pharmacological properties of known organic-based drugs, the present manuscript addresses the complexation of the antifungal agent voriconazole (vcz) with the biologically relevant silver(I) ion as a strategy for the development of new antimycotics. The synthesized silver(I) complexes with vcz were characterized by mass spectrometry, IR, UV-Vis and NMR spectroscopy and single-crystal X-ray diffraction analysis. The crystallographic results showed that complexes {[Ag(vcz)(HO)]CHSO} (1), {[Ag(vcz)]BF} (2) and {[Ag(vcz)]PF} (3) have polymeric structures in the solid state, in which silver(I) ions have a distorted tetrahedral geometry.
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