Publications by authors named "I Tshavuka Filippus"
[Potential Oncogenic Role of Genes in PLC Family on T-ALL Cell Lines by Suppression of Apoptosis].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2023
Article Synopsis
- The study investigates how the phospholipase C (PLC) family contributes to the development and progression of acute T lymphoblastic leukemia (T-ALL).
- Methods included analyzing cell death in T-ALL cells after using PLC inhibitors and assessing the influence of PLC expressions on patient survival using various statistical analyses.
- Results indicated that certain T-ALL cell lines were sensitive to PLC inhibitors, while others were resistant, and high expression of specific PLC genes was linked to poor patient prognosis, suggesting these genes could be potential targets for therapy.
Background: Oligochitosan has broad-spectrum antimicrobial activity and shows an obvious inhibitory effect on phytopathogens. In addition, as an exogenous elicitor, it can induce various defence responses, including affecting the activities of several defence-related enzymes and substances in some plants. Owing to this dual function of oligochitosan, it can be used to control postharvest diseases of fruits.
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