Publications by authors named "I Trestini"
Background: While immune checkpoint inhibitors (ICIs) are increasingly reshaping the therapeutic landscape of non-small-cell lung cancer (NSCLC), only a limited proportion of patients achieve a relevant and long-lasting benefit with these treatments, calling for the identification of clinical and, ideally modifiable, predictors of efficacy. Body composition phenotypes may reflect aspects of patients' immunology and thereby their ability to respond to ICIs. This study aims to explore the possible association between pre-treatment body composition phenotypes, tumour response, and clinical outcomes in patients receiving first-line pembrolizumab monotherapy for advanced NSCLC.
View Article and Find Full Text PDFWhereas an exercise intervention effectively improves patients' quality of life, little information is available about the contribution of each physical fitness component. This study aims to explore the association between physical fitness components and the quality-of-life domain in patients with cancer. Between September 2021 and August 2023, 160 patients with mixed cancer types visiting the Oncology Unit were selected on a consecutive basis according to selection criteria.
View Article and Find Full Text PDFBackground And Aims: Patients undergoing pancreatic resection are commonly malnourished. It is still unclear whether nutritional scores reliably predict postoperative outcomes after pancreatic resection. This study evaluated whether five commonly used preoperative nutritional screening scores predicted severe complications and length of stay.
View Article and Find Full Text PDFArticle Synopsis
- Advancements in antiemetic drugs have improved the management of chemotherapy-induced nausea and vomiting (CINV), but about 30% of adult patients still experience persistent symptoms, leading to complications.
- Supportive care interventions, including physical exercise and nutritional counseling, have proven effective in reducing CINV severity, while psychological interventions and acupuncture have also shown promise.
- The review aims to update current guidelines for preventing and treating CINV and to explore various non-drug interventions available for cancer patients.