Publications by authors named "I Tkac"
Background: There is no doubt that genetic factors have the potential to predict the therapeutic outcomes of antidepressants in patients with major depressive disorder (MDD). This study investigated the association between genetic variants involved in serotonin signaling and brain-derived neurotrophic factor (BDNF) with the response to escitalopram treatment in patients with MDD. We focused on examining the influence of 5-HTTLPR (ins/del), HTR2A rs9316233, BDNF rs962369, CYP2C19 and CYP2D6 on the clinical response to escitalopram.
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- The study looked at allergic breathing problems for people working in jobs like farming, food production, and textiles in Eastern Slovakia from 1990 to 2021.
- It found that the number of cases, especially occupational asthma (OA), has gone down over the years, particularly in farming jobs.
- Now, more people are getting these allergic issues from working with metalworking fluids (MWFs) in industrial manufacturing instead of from farming.
Objective: To determine sex differences in the neurochemical concentrations measured by proton magnetic resonance spectroscopy (H MRS) of healthy mice on a genetic background commonly used for neurodegenerative disease models.
Methods: H MRS data collected from wild type mice with C57BL/6 or related genetic backgrounds in seven prior studies were used in this retrospective analysis. To be included, data had to be collected at 9.
γ-Aminobutyric acid (GABA), as the primary inhibitory neurotransmitter, is extremely important for maintaining healthy brain function, and deviations from GABA homeostasis are related to various brain diseases. Short-echo-time (short-TE) proton MR spectroscopy ( H-MRS) has been employed to measure GABA concentration from various human brain regions at high magnetic fields. The aim of this study was to investigate the effect of spectral linewidth on GABA quantification and explore the application of an optimized basis-set preparation approach using a spectral-linewidth-matched (LM) basis set in LCModel to improve the reproducibility of GABA quantification from short-TE H-MRS.
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