Preclinical profile of the monodisperse iodinated macromolecular blood pool agent P743.

Rationale And Objectives: To summarize the chemical synthesis, physicochemical characterization, pharmacokinetic behavior, and biological evaluation of P743, a new macromolecular iodinated contrast medium.

Methods: The synthesis and molecular modeling of the iodinated macromolecule P743 are described. The pharmacokinetic profile was established in rabbits and rats.