Publications by authors named "I Thiele"
Genetic studies of the metabolome can uncover enzymatic and transport processes shaping human metabolism. Using rare variant aggregation testing based on whole-exome sequencing data to detect genes associated with levels of 1,294 plasma and 1,396 urine metabolites, we discovered 235 gene-metabolite associations, many previously unreported. Complementary approaches (genetic, computational (in silico gene knockouts in whole-body models of human metabolism) and one experimental proof of principle) provided orthogonal evidence that studies of rare, damaging variants in the heterozygous state permit inferences concordant with those from inborn errors of metabolism.
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- Human microbiomes play a crucial role in health by impacting metabolism, immune functions, and neurological processes, but their complete complexity is still not fully understood.
- The definition of a "healthy" microbiome is controversial due to variations in microbial communities and the difficulty in establishing a standard definition for health across different individuals and conditions.
- The article highlights progress in microbiome research and identifies gaps in knowledge, proposing a roadmap that utilizes epidemiological methods to better understand the relationship between microbiomes and health.
Article Synopsis
- Understanding the gut microbiome is crucial for sustainable aquaculture as it affects fish digestion, metabolism, health, and growth.
- The Salmon Microbial Genome Atlas has compiled 211 high-quality bacterial genomes from wild and farmed Atlantic salmon, revealing diverse taxonomic classifications and new species.
- The study characterized key bacterial populations that can break down dietary fibers and produce beneficial compounds, providing a valuable resource for future research on salmon nutrition and health.