POSTMORTEM INTERVAL ESTIMATION BY THE METHOD OF WAVELET ANALYSIS OF STOKES-POLARIMETRIC MAPPING DATA OF HUMAN VITREOUS BODY LAYERS.

Objective: The aim: To develop a set of forensic criteria for determining PMI on the basis of complex selective statistical data analysis of magnitude distributions of the wavelet-amplitude coefficients of VB polycrystalline films microscopic images.

Patients And Methods: Materials and methods: The object of study are polycrystalline films of VB, taken from 41 cadavers of both sexes aged from 37 to 79-year with pre-known time of death coming ranged from 3 to 36 h. Measuring the coordinate allocation meanings of parameters of polarization in the points of microscopic images was carried out at the location of the standard Stokes-polarimeter.

Comparison of 5 Ki-67 antibodies regarding reproducibility and capacity to predict prognosis in breast cancer: does the antibody matter?

Although several antibodies are available for immunohistochemical detection of Ki-67, even the most commonly used MIB-1 has not been validated yet. Our aim was to compare 5 commercially available antibodies for detection of Ki-67 in terms of agreement and their ability in predicting prognosis of breast cancer. Tissue microarrays were constructed from 378 breast cancer patients' representative formalin-fixed, paraffin-embedded tumor blocks.

Changes of protein expression in prostate cancer having lost its androgen sensitivity.

Objective: The majority of prostate cancers require androgen hormones for growth, and androgen ablation is an important part of the systemic treatment of advanced prostate cancer. Nevertheless, most of these cancers eventually relapse as they become less sensitive to androgen ablation and anti-androgen treatment. Elucidating the molecular events that are responsible for the conversion of androgen-sensitive cancers to androgen-refractory tumors may reveal new therapeutic opportunities.

Connexin 43 communication channels in follicular dendritic cell development and in follicular lymphomas.

Follicular dendritic cells (FDC) show homo- and heterocellular metabolic coupling through connexin 43 (Cx43) gap junctions and support B cell selection and maturation in germinal centers. In follicular lymphomas B cells escape apoptosis while FDC develop abnormally. Here we tested Cx43 channels in reactive FDC development and follicular lymphomas.

Correlations of differentially expressed gap junction connexins Cx26, Cx30, Cx32, Cx43 and Cx46 with breast cancer progression and prognosis.

Background And Aims: Connexins and their cell membrane channels contribute to the control of cell proliferation and compartmental functions in breast glands and their deregulation is linked to breast carcinogenesis. Our aim was to correlate connexin expression with tumor progression and prognosis in primary breast cancers.

Materials And Methods: Meta-analysis of connexin isotype expression data of 1809 and 1899 breast cancers from the Affymetrix and Illumina array platforms, respectively, was performed.