Publications by authors named "I Tamayo-Uria"
Article Synopsis
- Glypican-3 (GPC3) is a potential target for T-cell therapy in hepatocellular carcinoma (HCC), but current CAR T-cell approaches face issues like low persistence and GPC3 shedding.
- Researchers immunized HLA-A2 transgenic mice to find GPC3-specific T-cell receptors (TCRs) and engineered human T cells (TCR-Ts) that effectively recognize GPC3-positive HCC cells.
- TCR-B-T cells showed superior effectiveness compared to traditional CAR T-cells, and combining CAR-T and TCR-B-T cells may enhance therapeutic results in treating HCC.
Background: Neoantigens, new immunogenic sequences arising from tumor mutations, have been associated with response to immunotherapy and are considered potential targets for vaccination. Hepatocellular carcinoma (HCC) is a moderately mutated tumor, where the neoantigen repertoire has not been investigated. Our aim was to analyze whether tumors in HCC patients contain immunogenic neoantigens suitable for future use in therapeutic vaccination.
View Article and Find Full Text PDFEpidemiological studies mostly focus on single environmental exposures. This study aims to systematically assess associations between a wide range of prenatal and childhood environmental exposures and cognition. The study sample included data of 1298 mother-child pairs, children were 6-11 years-old, from six European birth cohorts.
View Article and Find Full Text PDFArticle Synopsis
- Tobacco is the primary risk factor for lung cancer, but the study investigates why some heavy smokers develop lung cancer at a young age while others do not develop it at all, even at advanced ages.
- Researchers conducted whole exome sequencing on 100 heavy smokers, dividing them into two groups: one that developed lung adenocarcinoma early (extreme cases) and one that remained cancer-free into old age (extreme controls).
- They found 619 genetic variants that differed significantly between the two groups, with nine variants in important cancer-related genes being statistically validated, potentially aiding in identifying high-risk individuals and developing new treatments.
Background: Environmental exposures in early life influence the development of behavioral outcomes in children, but research has not considered multiple exposures. We therefore aimed to investigate the impact of a broad spectrum of pre- and postnatal environmental exposures on child behavior.
Methods And Findings: We used data from the HELIX (Human Early Life Exposome) project, which was based on six longitudinal population-based birth cohorts in Europe.