Publications by authors named "I T Velasco"
Female reproduction is highly sensitive to body energy stores; persistent energy deficit, as seen in anorexia or strenuous exercise, is known to suppress ovulation via ill-defined mechanisms. We report herein that hypothalamic SIRT1, a key component of the epigenetic machinery that links nutritional status and puberty onset via modulation of Kiss1, plays a critical role in the control of the preovulatory surge of gonadotropins, i.e.
View Article and Find Full Text PDFThe neurobiological mechanisms underlying major depressive disorder (MDD) remain largely unexplored due to the limited availability of study models in humans. Induced pluripotent stem cells (iPSCs) have overcome multiple limitations of retrospective clinical studies, contributing to a more detailed understanding of the molecular pathways that presumably contribute to the manifestation of depression. Despite the significant progress made by these study models, there are still more formidable challenges that will eventually be addressed by these platforms, as further studies may eventually emerge.
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- * This review focuses on the intrinsic differences between SNc and VTA neurons, including aspects like gene expression, calcium dynamics, energy metabolism, and responses to reactive oxygen species (ROS), particularly during aging.
- * Key findings indicate that SNc neurons have higher energy demands and ROS production due to their complex structure, making them more prone to degeneration, especially when affected by PD-related mutations impacting metabolic pathways.
Article Synopsis
- Polycystic ovary syndrome (PCOS) is a complex condition characterized by irregular ovulation, high levels of androgens, and the presence of polycystic ovaries, often leading to metabolic issues like obesity and insulin resistance.
- Current treatments mainly address symptoms but are often ineffective for the underlying metabolic and reproductive problems.
- Research shows that a GLP1-based treatment, specifically GLP1/Estrogen (GLP1/E), is more effective in managing PCOS-related metabolic complications and improving ovulation than other multi-agonists and metformin, suggesting a more personalized approach to treatment.
Introduction: Southern Hemisphere countries have been underrepresented in epidemiological studies on acute kidney injury (AKI). The objectives of this study were to determine the frequency, risk factors, and outcomes of AKI in adult hospitalized patients from the emergency department of a public high-complexity teaching hospital in the city of São Paulo, Brazil.
Methods: Observational and prospective study.