Solid State Self-Assembly of an Extended Curved-Arm Nickel(II) Macrocycle with Fullerene C.

Three new co-crystalline structures are reported that contain fullerene C with the under-represented Ni(II)-dibenzotetraaza[14]annulene derivative, (5,14-dihydro-6,8,15,17-tetrabenzyl-2,3,11,12-tetramethyldibenzo[b,i][1,4,8,11]tetraazacyclo-tetradecine)nickel(II), [Ni(BzTMTAA)]. The single-crystal X-ray analysis shows that the three studied compounds crystallize in the monoclinic C2/c, Pnma orthorhombic and triclinic P space groups, with the two former compounds being polymorphs that are isostructural but differ in their symmetries. From the crystallographic results, a common packing arrangement is established, with C and [Ni(Bz4TMTAA)] molecules organised around one-dimensional hollow channels, associated 1 : 1 and 1 : 2 complexation of the macrocycle and the fullerene molecules, the latter being organised into hexagonal arrays.

SuperMap algorithm: an efficient, safe and accurate modality for mapping and eliminating challenging cardiac arrhythmias.

Even with the development of advanced catheter-based mapping systems, there remain several challenges in the electrophysiological evaluation and elimination of atrial arrhythmias. For instance, atrial tachycardias with irregular rates cannot be reliably mapped by systems that require stability in order to sequentially gather data points to be organized thereafter. Separately, these arrhythmias often arise following initial ablation for atrial fibrillation, posing logistic challenges.

The complement regulator CD55 modulates TLR9 signaling and supports survival in marginal zone B cells.

Marginal zone (MZ) B cells bridge innate and adaptive immunity by sensing bloodborne antigens and producing rapid antibody and cytokine responses. CD55 is a membrane-bound complement regulator that interferes with complement activation, an important component of innate immunity. CD55 also regulates adaptive immunity-CD55 downregulation is critical for germinal center reactions.