Publications by authors named "I T Higgins"
Introduction: Alzheimer's disease is partially characterized by the progressive accumulation of aggregated tau-containing neurofibrillary tangles. Although the association between accumulated tau, neurodegeneration, and cognitive decline is critical for disease understanding and clinical trial design, we still lack robust tools to predict individualized trajectories of tau accumulation. Our objective was to assess whether brain imaging biomarkers of flortaucipir-positron emission tomography (PET), in combination with clinical and genomic measures, could predict future pathological tau accumulation.
View Article and Find Full Text PDFBackground: Rejection from parents can lead transgender (trans) youth and young adults to experience poor health outcomes, while parental and sibling acceptance and support can be protective against poor health outcomes. The role of family in adult trans women's lives has been minimally investigated.
Aim: This study aimed to explore experiences of familial rejection, acceptance, and support in the lives of trans women sex workers living with HIV in the Dominican Republic.
Article Synopsis
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect multiple organs, with kidney issues (lupus nephritis) being a serious complication and a leading cause of death in affected patients.
- Current mouse models used to study SLE/LN show diverse immune responses that may not fully reflect human disease, highlighting the need for better models that parallel human pathways for developing new treatments.
- The research compared the immune responses of five different mouse models of SLE/LN to human data, finding differences in cell types and responses, which could help in understanding the disease and improving therapy translation for patients.
Latinos in the United States are disproportionately affected by HIV and experience sub-optimal levels of viral suppression. Enlaces Por La Salud is an individual-level intervention implemented by personal health navigators and guided by the transnational framework to improve HIV care outcomes among newly diagnosed and out-of-care Mexican and Mexican American men and transgender women in North Carolina. The purpose of this study was to assess: (1) changes in HIV care and treatment outcomes among Enlaces participants and (2) intervention engagement and experiences.
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