Antihypertensive effect of bopindolol: a multi-centre study.

The objective of the study was to investigate the efficacy of different dose levels of bopindolol monotherapy in hypertension. This potent nonselective beta-adrenergic receptor blocker has intrinsic sympathomimetic activity and long duration of action. Forty-four patients with essential hypertension of mild (n = 40) or moderate (n = 4) severity (90 less than DBP less than or equal to 115 mmHg at the end of the placebo period) entered and completed the single-blind, placebo-controlled trial.

[Hann syndrome: remission of diabetes insipidus by functional failure of the anterior pituitary gland].

We know that the symptoms of diabetes insipidus develop only in a state of functional capacity of the neurohypophysis. The symptomatology of diabetes insipidus disappears, when the pars anterior of the hypophysis is destructed, whereas the two lobes have antagonistic effects in respect of water metabolism. Describing two cases the authors remember to F.