Publications by authors named "I Suarez Lorenzo"
Article Synopsis
- The International Mouse Phenotyping Consortium (IMPC) creates and studies mouse lines with specific gene mutations to better understand gene functions, using advanced techniques such as the Cas9 nuclease for enhanced efficiency.
- The IMPC has produced 3313 knockout mouse lines, allowing for a comprehensive analysis of factors that influence successful gene editing in living organisms.
- The research highlights that the essentiality of genes significantly affects the success rates in producing null alleles, and offers best practice guidelines for using Cas9 in gene engineering linked to human diseases.
In this retrospective cohort study the survival rate, clinical parameters, patient satisfaction with aesthetics and oral health-related quality of life of 3D printed temporary crowns were evaluated. Temporary crowns were 3D printed with a Form3B out of Permanent Crown Resin (Formlabs GmbH). Anonymized data for the restorations' survival (in-situ) was evaluated retrospectively for 98 temporary crowns of 63 patients fabricated within 19 months.
View Article and Find Full Text PDFOsteogenesis imperfecta (OI) type V is the second most common form of OI, distinguished by hyperplastic callus formation and calcification of the interosseous membranes, in addition to the bone fragility. It is caused by a recurrent, dominant pathogenic variant (c.-14C>T) in interferon-induced transmembrane protein 5 (IFITM5).
View Article and Find Full Text PDFTime-lapse microscopy for embryos is a non-invasive technology used to characterize early embryo development. This study employs time-lapse microscopy and machine learning to elucidate changes in embryonic growth kinetics with maternal aging. We analyzed morphokinetic parameters of embryos from young and aged C57BL6/NJ mice via continuous imaging.
View Article and Find Full Text PDFBackground: This retrospective study focused on analyzing community-acquired respiratory virus (CARV) infections, in particular human parainfluenza virus (hPIV) after allogeneic stem cell transplant (allo-SCT) in adults recipients. It aimed to assess the impact of ribavirin treatment, clinical characteristics, and risk factors associated with lower respiratory tract disease (LRTD) progression and all-cause mortality.
Patients And Methods: The study included 230 allo-SCT recipients diagnosed with hPIV between December 2013 and June 2023.