Publications by authors named "I Strina"
Background: Intensive physical activity and rigid dietary regimes can act as modifiers of neuroendocrine axes in women, inducing hormonal disorders and related menstrual irregularities such as functional hypothalamic amenorrhea (FHA). It would be important to evaluate if such disturbances may worsen female fertility. The aim of this study was to evaluate ovarian reserve markers and neuroendocrine axis in young military academy female cadets with years of training and occurrence of FHA.
View Article and Find Full Text PDFControlled ovarian stimulation leads to cardiovascular changes in patients undergoing in vitro fertilization.
Eur J Obstet Gynecol Reprod Biol
September 2024
Article Synopsis
- The study aimed to analyze changes in hemodynamics (blood flow and heart function) during controlled ovarian stimulation in women undergoing in vitro fertilization at a hospital in Naples, Italy.
- It included 68 infertile patients and assessed their cardiovascular parameters at three key time points: baseline, estradiol peak, and embryo transfer day.
- The results indicated significant changes in cardiac output and stroke volume index at these time points, highlighting the impact of ovarian stimulation on maternal cardiovascular health, particularly in patients at risk of hyperstimulation.
Semaphorin 3A (SEMA3A) plays a crucial role in the development, differentiation, and plasticity of specific types of neurons that secrete Gonadotropin-Releasing Hormone (GnRH) and regulates the acquisition and maintenance of reproductive competence in humans and mice. Its insufficient expression has been linked to reproductive disorders in humans, which are characterized by reduced or failed sexual competence. Various mutations, polymorphisms, and alternatively spliced variants of SEMA3A have been associated with infertility.
View Article and Find Full Text PDFAssessing ovarian stimulation with letrozole and levonorgestrel intrauterine system after combined fertility-sparing approach for atypical endometrial lesions: a retrospective case-control study.
Reprod Biomed Online
May 2024
Research Question: Is ovarian stimulation with levonorgestrel intrauterine system (LNG-IUS) in situ and co-treatment with letrozole safe and effective in patients undergoing fertility-sparing combined treatment for atypical endometrial hyperplasia (AEH) or early endometrial cancer limited to the endometrium?
Design: Retrospective case-control study recruiting women who had undergone fertility-sparing 'combined' treatment and ovarian stimulation with letrozole and LNG-IUS in situ. The 'three steps' hysteroscopic technique was used. Once complete response was achieved, the ovaries were stimulated, and mature oocytes cryopreserved.