Publications by authors named "I Steinke"
Background: The increased incidence of Alzheimer's disease (AD) rate represent an unmet medical need and thus critical for the development of novel molecular therapeutics. Recent work focusing on patients with apoE4 alleles has highlighted the association of brain cholesterol dysregulation with elevated pathological burden and neurodegeneration. These studies have highlighted the importance of the nuclear receptor Liver X receptor (LXR) for developing AD therapies.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is characterized by hallmark amyloid plaques and neurofibrillary tangles as well as by a significant loss of myelin in the cerebral cortex and other brain regions, which contributes to neurodegeneration and cognitive decline. Remyelination, of the myelin sheath by oligodendrocytes, is a process that may be impaired in neurodegenerative diseases. Depending on the severity of the disease, there occurs loss or partial damage of the myelin sheath surrounding the neuron leading to memory deficits.
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- * This study focused on measuring the ice nucleation rate of 2-methyltetrols (2-MT), a component of certain organic aerosols, and found that as the aerosol's viscosity increases, its ice nucleation ability also increases significantly, especially when transitioning from liquid to semisolid states.
- * A new model based on classical nucleation theory was created to quantify the relationship between viscosity and ice nucleation rate, which can be used in climate models to better represent cir
Article Synopsis
- The enzyme Asparaginyl Endopeptidase (AEP) is linked to serious brain disorders like Alzheimer's and Frontotemporal Dementia, where it contributes to neurodegeneration through the formation of harmful protein aggregates.
- Despite its significance in these conditions, there are currently no approved small molecule inhibitors for AEP, highlighting a critical need for new treatments.
- Researchers used a computer-aided drug design approach to analyze over 10 million compounds, identifying six potential AEP inhibitors (AEPI-1 to AEPI-6) that show strong binding affinity and stability, making them promising candidates for drug development.