Background: Elevated exhaled nitric oxide fraction at a flow rate of 50 mL·s ( ) is an important indicator of T-helper 2-driven airway inflammation and may aid clinicians in the diagnosis and monitoring of asthma. This study aimed to derive Global Lung Function Initiative reference equations and the upper limit of normal for .
Methods: Available individual data were collated and harmonised using consensus-derived variables and definitions.
Am J Respir Crit Care Med
March 2023
The use of self-reported race and ethnicity to interpret lung function measurements has historically assumed that the observed differences in lung function between racial and ethnic groups were because of thoracic cavity size differences relative to standing height. Very few studies have considered the influence of environmental and social determinants on pulmonary function. Consequently, the use of race and ethnicity-specific reference equations may further marginalize disadvantaged populations.
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