Objectives: Bone remodelling is a highly dynamic process dependent on the precise coordination of osteoblasts and haematopoietic-cell derived osteoclasts. Changes in core metabolic pathways during osteoclastogenesis, however, are largely unexplored and it is unknown whether and how these processes are involved in bone homeostasis.
Methods: We metabolically and transcriptionally profiled cells during osteoclast and osteoblast generation.
Objectives: TNF-induced activation of fibroblast-like synoviocytes (FLS) is a critical determinant for synovial inflammation and joint destruction in RA. The detrimental role of TNF-receptor 1 (TNFR1) has thoroughly been characterized. The contributions of TNFR2, however, are largely unknown.
View Article and Find Full Text PDFBackground: We investigated whether the results of autonomic function tests correlate with body composition and shape in healthy young people.
Methods: We conducted cardiovascular reflex tests (heart rate [HR] and blood pressure [BP] responses to the Valsalva maneuver and HR response to deep breathing) and the tilt table test with 32 subjects (19 males; mean age, 22.1±1.
Objectives: To investigate a possible association between autonomic dysfunction and fatigue in people with multiple sclerosis.
Methods: In 70 people with multiple sclerosis early in the disease course (51 females, mean age 33.8 ± 9.