Publications by authors named "I Somasundaram"
Article Synopsis
- - The study investigates the role of endometrial stem cells (eSCs) in tissue regeneration and angiogenesis, particularly focusing on CD146 as a key marker that enhances the regenerative and vascular growth potential of these cells.
- - Researchers isolated eSCs from biopsies of active reproducing women and conducted various analyses to assess their properties, including growth factor secretion and angiogenic capabilities, using functional assays.
- - The findings potentially pave the way for innovative eSC-based therapies in regenerative medicine and the treatment of vascular disorders by understanding CD146's influence on eSCs' angiogenic functions.
Aging is a complex process that features a functional decline in many organelles. Various factors influence the aging process, such as chromosomal abnormalities, epigenetic changes, telomere shortening, oxidative stress, and mitochondrial dysfunction. Mitochondrial dysfunction significantly impacts aging because mitochondria regulate cellular energy, oxidative balance, and calcium levels.
View Article and Find Full Text PDFBackground: CD146, a cell adhesion molecule, was first discovered in melanoma. Since then, it has been established as a promoter of tumor progression and metastasis. Many recent clinical studies have associated CD146 overexpression with poor prognosis in various cancers.
View Article and Find Full Text PDFBackground: The therapeutic effectiveness of mesenchymal stem cells (MSCs) and their secretome can be enhanced by means of physical, chemical and biological preconditioning. 30C (AA30) has been one of the leading homeopathic medicines used in prophylaxis against SARS-CoV-2 infection.
Aims: This study aimed to investigate whether AA30 preconditioning could influence the growth factors and cytokine profile of the human dental pulp-derived MSC (DPD-MSC) secretome.
Senotherapy, a promising therapeutic strategy, has drawn a lot attention recently due to its potential for combating cancer. Senotherapy refers to the targeting of senescent cells to restore tissue homeostasis and mitigate the deleterious effects associated with senescence. Senolytic drugs represent a promising avenue in cancer treatment, with the potential to target and modulate senescent cells to improve patient outcomes.
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