The evidence for an etiological relationship between oral contraceptive use and dysplastic change in cervical tissue.

A case-control study of 112 patients with cervical intraepithelial neoplasia (CIN) and 131 control subjects was conducted. Estradiol receptor levels were determined in the total (cytosolic-nucleosolic) fraction of the neoplastic cervical specimens taken during the late proliferative phase of their cycle from 58 premenopausal patients who had been oral contraceptive (OC) users for at least 2 years and from 54 premenopausal women who had not been OC users. All specimens contained variable amount of estradiol receptor (from 7.

[Plasma concentration of biochemical markers in pre-eclampsia-eclampsia and its association with the severity of the disease].

Unlabelled: It has been demonstrated that the concentrations of molecules related to endothelial cell dysfunction, coagulation and vasoconstriction are altered in preeclamptic patients, but they have not been evaluated in their relationship with the severity of preeclampsia.

Objective: To determine the relationship between the plasmatic concentrations of fibronectin ED1+, antithrombin III, prostacyclin and thromboxane, and the severity of preeclampsia.

Methods: Peripheral blood was collected from 215 women in the third trimester of pregnancy, admitted to the Luis Castelazo Ayala Gynecology and Obstetrics Hospital with mild preeclampsia (n = 103), severe preeclampsia (n = 71), HELLP syndrome (n = 25) or eclampsia (n = 16).

[The process of cell degeneration].

It is well conceived that the intention of man in trying to solve human kind ailments, is being a long standing biological rule to give rational solutions at any rate. The response to the current problem studied, approaches a different view of the peripheral and local deteriorating phenomena and offers--in a non classical way--how to maintain the well-being of a population of otherwise healthy women, in trying to defer the degenerative cellular process. Interesting, as the proximity of the XXI century arrives, the technology and the biomedical level of progress seems to be for a way from the ideal, particularly when dealing with a process initiated years before the menopause.

Disturbing the light-darkness pattern reduces circulating testosterone in healthy men.

This is an analytic-sagital-observational-endocrinological study of the environmental stress induced by disturbing the light-darkness pattern. A population of 15 males, ages 28-59 years old, participated at random. All had had a pattern sleep of 22:00-6:00 h.

[Health status in the population using contraceptives].

In order to partially understand the health status of women under contraceptive therapy and their possible social hazard of it, a descriptive, prospective and transversal study was undertaken in a 500 individuals, ages 20-35 years old, who currently were regulation their fertility. Data were obtained by means of predetermined questions from subjects attending several clinics of the IMSS. Anyone refusing to participate was discharged questions.