[Liver transplantation and peri-operative changes to renal function].

The Aim Of The Study: Was to analyze in detail perioperative changes of renal function during orthotopic liver transplantation (OLT) and to identify risk factors, that were associated with the need of renal replacement therapy (RRT) during the first week after liver transplantation.

Methods: Prospective study of 50 consecutive patients undergoing OLT was performed. Selected laboratory and clinical parameters were monitored prior to the procedure, after reperfusion, at the end of the procedure, and at 12 hours after the procedure.

The auxiliary table for GFR estimation according to the MDRD formula.

The best overall index of renal function is considered to be glomerular filtration rate (GFR) and the gold standard for its assessment is renal inulin clearance (Cin) Unfortunately, Cin cannot be routinely used in daily practice due to its complexity as a test. The most often used ones are the Cockcroft-Gault (CG) formula and the recently developed Modification of Diet in Renal Disease (MDRD) prediction equation. Calculation of MDRD (estimated GFR) according to this formula is simple but it requires a computer program.

[Thromboelastography in liver transplantation, a comparison with conventional laboratory tests].

Background: The aim of our study was to compare the results of conventional tests and thromboelastography during liver transplantation and to determine their importance for blood loss.

Methods And Results: Thromboelastography and conventional laboratory tests were undertaken in 25 patients at the end of the anhepatic phase. Transfusion requirements correlated significantly only with prothrombin time and reaction time, R.

[A negative interference effect of pathologic levels of bilirubin on the determination of serum creatinine].

Background: Negative interference of bilirubin with assessment of creatinine concentration is generally known from the biochemical aspect. The objective of the presented work was to find the bilirubin level and creatinine concentration where this phenomenon has actually a clinical impact.

Methods And Results: In 200 samples selected at random the bilirubin and creatinine levels were examined by the classical Jaffé method and a method where the effect of bilirubin is suppressed.

[Pulsed doses of calcitriol in the treatment of secondary hyperparathyroidism in patients on hemodialysis].

Administration of pulse doses of calcitriol is a better way of conservative treatment of secondary hyperparathyroidism (2HPT), making use of the direct suppression of parathormone (PTH) secretion. In a group of 29 haemodialyzed patients the authors evaluated during a six-month follow-up the effect of intravenous Calcijex in 12 and of oral Rocaltrol in 8 subjects. In responders of the calcijex group the PTH level declined by 67.