Publications by authors named "I Slaby"
Background: Neurodevelopmental disorders (NDDs), such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), are examples of complex and partially overlapping phenotypes that often lack definitive corroborating genetic information. ADHD and ASD have complex genetic associations implicated by rare recurrent copy number variations (CNVs). Both of these NDDs have been shown to share similar biological etiologies as well as genetic pleiotropy.
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- ADHD often presents with other mental health issues in children, making it hard to determine what symptoms are due to ADHD and what are from the comorbid conditions, complicating treatment approaches.
- An electronic algorithm was developed to accurately differentiate between cases of ADHD alone and cases where ADHD occurs with other psychiatric disorders, using data from electronic health records (EHRs) at the Children's Hospital of Philadelphia.
- This algorithm enhances research efforts by allowing better classification of ADHD and its comorbidities, facilitating future genetic studies and improving understanding of ADHD's impact on children.
Article Synopsis
- The study investigated how transcranial direct current stimulation (tDCS) on the left temporoparietal junction (TPJ) affects humor appreciation during comedy video ratings.
- Participants rated the humor of stand-up comedy videos while receiving different types of electrical stimulation (anodal, cathodal, or none), which targeted the TPJ area of the brain.
- Results indicated that anodal stimulation decreased humor ratings compared to the other conditions, suggesting that stimulating the TPJ may interfere with understanding aggressive humor by altering mental processes related to empathy and theory of mind.
Tooth enamel, the hardest tissue in the body, is formed by the evolutionarily highly conserved biomineralization process that is controlled by extracellular matrix proteins. The intrinsically disordered matrix protein ameloblastin (AMBN) is the most abundant nonamelogenin protein of the developing enamel and a key element for correct enamel formation. AMBN was suggested to be a cell adhesion molecule that regulates proliferation and differentiation of ameloblasts.
View Article and Find Full Text PDFAmeloblastin (AMBN) is a protein expressed mainly during dental hard tissue development. Biochemically, it is classified as an intrinsically disordered protein (IDP). Its biological role remains largely unknown; however, the question of AMBN function will undoubtedly be connected to its structural properties and its potential for protein-protein and protein-cell interactions.
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