Publications by authors named "I Six"
Stiffening of the vascular network is associated with the early stages of vascular aging, leading to cardiovascular disorders (hypertension), renal failures, or neurodegenerative diseases (Alzheimer's). Unfortunately, many people remain undiagnosed because diagnostic methods are either unsuitable for a large population or unfamiliar to clinicians which favor the hypertension evaluation. In preclinical research, stiffness studies are often partially conducted.
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- Acute kidney injury (AKI) can progress to acute kidney disease (AKD) and potentially to chronic kidney disease (CKD), creating significant health risks, including cardiovascular complications.
- In a mouse study, researchers found that kidney injury resulted in early heart and blood vessel dysfunction, marked by specific changes in protein expression and increased levels of harmful toxins over time.
- The findings emphasize the importance of understanding the early effects of AKD on cardiovascular health to find ways to prevent future heart issues.
Article Synopsis
- Type 2 diabetes (T2D) is a significant public health crisis, leading to 6.7 million premature deaths in 2022 due to cardiovascular complications, which are greatly intensified by the disease.
- The study investigates the aging process of the extracellular matrix (ECM) in diabetic mice, revealing that their aorta shows signs of premature aging similar to older, nondiabetic mice, particularly regarding collagen and elastic fiber degradation.
- Findings suggest that these premature changes in the ECM contribute to vascular rigidity, increasing the likelihood of serious conditions like hypertension and atherosclerosis, which may explain the heightened risk of cardiovascular disease and early mortality in T2D patients.
Bone diseases are increasing with aging populations and it is important to identify clues to develop innovative treatments. Vasn, which encodes vasorin (Vasn), a transmembrane protein involved in the pathophysiology of several organs, is expressed during the development in intramembranous and endochondral ossification zones. Here, we studied the impact of Vasn deletion on the osteoblast and osteoclast dialog through a cell Coculture model.
View Article and Find Full Text PDFObjectives: To evaluate extracellular vesicles levels in a cohort of SARS-CoV-2's patients hospitalized in an intensive care unit with and without COVID-19 associated thromboembolic events.
Methods: In this study, we aim to assess endothelial and platelet membrane-derived extracellular vesicles levels in a cohort of SARS-CoV-2 patients with and without COVID-19-associated thromboembolic events who were hospitalized in an intensive care unit. Annexin-V positive extracellular vesicles levels were prospectively assessed by flow cytometry in one hundred twenty-three critically ill adults diagnosed with acute respiratory distress syndrome associated with a SARS-CoV-2 infection, ten adults diagnosed for moderate SARS-CoV-2 infection and 25 healthy volunteers.