Publications by authors named "I Singh-Minott"
This study aims to assess coronavirus disease 2019 (COVID-19) surveillance methods, health resources, vaccination coverage and income stratification and quantify burdens of disease and death in children and adolescents in the Caribbean. The investigation was a descriptive, cross-sectional study that included 15 Caribbean countries/territories and utilized surveys and secondary data sources. Quarantine and isolation measures were robust and surveillance strategies were similar.
View Article and Find Full Text PDFObjective: To assess pregnancy and fetal outcomes in Jamaican subjects with sickle cell-haemoglobin C (SC) disease.
Study Design: A retrospective chart review over 21 years (1992-2012) of all pregnancies in SC disease and a comparison group matched by gender and date of delivery in mothers with a normal haemoglobin (AA) phenotype at the University Hospital of the West Indies, Jamaica. There were 118 pregnancies in 81 patients with SC disease and 110 pregnancies in 110 in the normal comparison group.
A case report of isoniazid-resistant disseminated tuberculosis in a young child perinatally co-infected with human immunodeficiency virus (HIV-1) and the challenges managing this child in a resource-constrained setting.
View Article and Find Full Text PDFArticle Synopsis
- Paediatric and Perinatal HIV/AIDS pose major health issues in the Caribbean, particularly in Jamaica, where the HIV prevalence is the second-highest globally.
- A collaborative initiative was launched in Greater Kingston to improve prevention and treatment for pregnant women and children, utilizing a five-point plan focused on leadership, pMTCT, comprehensive care, research, and outreach.
- Significant advancements were made from 2002 to 2007, including increased uptake of counselling and HIV testing, and a marked decrease in mother-to-child transmission rates, from 29% to as low as 1.6%, due to effective treatment protocols.
Perinatal HIV infection is characterized by a sustained high-level viremia and a high risk of rapid progression to AIDS, indicating a failure of immunologic containment of the virus. We hypothesized that age-related differences in the specificity or function of HIV-specific T cells may influence HIV RNA levels and clinical outcome following perinatal infection. In this study, we defined the HIV epitopes targeted by 76 pediatric subjects (47 HIV infected and 29 HIV exposed, but uninfected), and assessed the ability of HIV-specific CD8 and CD4 T cells to degranulate and produce IFN-gamma, TNF-alpha, and IL-2.
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