Publications by authors named "I Simon"
While the majority of proteins with available structures are able to fold independently and mediate interactions only after acquiring their folded state, a subset of the known protein complexes contains protein chains that are intrinsically disordered in isolation. The Mutual Folding Induced by Binding (MFIB) database collects and classifies protein complexes, wherein all constituent protein chains would be unstable/disordered in isolation but fold into a well-defined 3D complex structure upon binding. This phenomenon is often termed as cooperative folding and binding or mutual synergistic folding (MSF).
View Article and Find Full Text PDFWomen 's perception on the quality of maternal and newborn care during the COVID-19 pandemic in German-speaking countries: Findings from the IMAgiNE EURO project comparing data from Germany, Switzerland and Austria.
Midwifery
January 2025
Article Synopsis
- Restrictions during the COVID-19 pandemic negatively impacted maternal and newborn care (QMNC) across Germany, Switzerland, and Austria, with varying strictness in protective measures implemented.
- An online survey collected data from 1,875 women who gave birth in these countries, revealing that Switzerland had better QMNC scores compared to Germany and Austria, particularly in the "Experience of care" sub-index.
- The study found weak to strong correlations between reorganizational changes due to COVID-19 and other QMNC areas, highlighting the need for continued research to enhance care quality post-pandemic.
Pancreatic cancer (PC) is an intricate malignancy with poor prognosis. In the present state of the art review paper and clinical trial trend analysis, we explore the current clinically employed state of pancreatic cancer body of knowledge and future research directions. When considering PDACs' molecular biology, we underline the role of PanIN in carcinogenesis and mutational gain, as well as the distinctive tumor microenvironment with the characteristic dense fibrotic stroma.
View Article and Find Full Text PDFConductive polymer composites are commonly present in flexible electrodes for neural interfaces, implantable sensors, and aerospace applications. Fused filament fabrication (FFF) is a widely used additive manufacturing technology, where conductive filaments frequently contain carbon-based fillers. In this study, the static and dynamic mechanical properties and the electrical properties (resistance, signal transmission, resistance measurements during cyclic tensile, bending and temperature tests) were investigated for polylactic acid (PLA)-based, acrylonitrile butadiene styrene (ABS)-based, thermoplastic polyurethane (TPU)-based, and polyamide (PA)-based conductive filaments with carbon-based additives.
View Article and Find Full Text PDFArticle Synopsis
- Non-polio enteroviruses (NPEV) are viruses that can cause serious illness around the world.
- Scientists are studying blood samples to learn about how these viruses have spread in the past and what might happen in the future.
- A recent test with twelve labs showed that there are big differences in how they measure NPEV antibodies, which means we need better standard rules for testing them.