Publications by authors named "I Sigala"
Pulmonary Embolism in Critically Ill Patients-Prevention, Diagnosis, and Management.
Diagnostics (Basel)
October 2024
Article Synopsis
- Critically ill patients in the ICU are often immobilized and on mechanical ventilation, increasing their risk for thromboembolic diseases like deep vein thrombosis (DVT) and pulmonary embolism (PE).
- Managing DVT and PE in the ICU is different from doing so in the emergency department, as existing guidelines mainly focus on emergency settings and don't account for the complexities of critically ill patients.
- This review seeks to summarize data and provide practical recommendations for the prevention, diagnosis, and treatment of PE specifically in ICU patients.
Article Synopsis
- Severe traumatic brain injury (sTBI) is a significant health issue, leading to around 300,000 ICU admissions each year and having a 30% mortality rate, which highlights the need for improved management despite low treatment evidence.
- The occurrence of pulmonary embolism (PE) in sTBI patients complicates treatment due to the risks associated with anticoagulating an already injured brain.
- A literature review was conducted, analyzing recent studies on sTBI and PE, resulting in 38 relevant papers that discuss the prevalence, risk factors, diagnostic challenges, prophylaxis timing, and treatment options for PE in these patients.
Acridones present numerous pharmacological activities, including inhibition of microtubule affinity-regulating kinase 4 (MARK4) kinase activity. To investigate structure-activity relationships and develop potent MARK4 inhibitors, derivatives of 2-methylacridone were synthesized and tested for their activity against MARK4 kinase. Selective substitutions at the nitrogen atom were accomplished by treating 2-methylacridone with alkyl halides in the presence of KCO.
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- This study explored the effectiveness of an 8-week rehabilitation program combined with usual care for COVID-19 pneumonia patients, comparing it with usual care alone.
- The program aimed to improve respiratory symptoms, fatigue, and overall quality of life among participants seven weeks post-hospital discharge.
- Results showed that those in the rehabilitation group had significant improvements in various health metrics, including reduced fatigue levels and enhanced physical and mental well-being.
Peptide-drug conjugates are delivery systems for selective delivery of cytotoxic agents to target cancer cells. In this work, the optimized synthesis of JH-VII-139-1 and its c(RGDyK) peptide conjugates is presented. The low nanomolar SRPK1 inhibitor, JH-VII-139-1, which is an analogue of Alectinib, was linked to the αβ targeting oligopeptide c(RGDyK) through amide, carbamate and urea linkers.
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