Comprehensive Analysis of Thrombotic Microangiopathy Following Renal Transplantation.

Thrombotic microangiopathy is a severe complication of renal transplantation. Little is known about risk factors, incidence of autoantibodies against complement components, and prognosis. Clinical and laboratory data were retrospectively collected for 13 patients diagnosed with post-transplant thrombotic microangiopathy (PT-TMA) in 2011-2018.

A rare case report of neonatal iliopsoas abscess presenting as swelling of left hip.

We report the case of a 12 days old baby boy who presented with swelling and bluish discoloration on his left hip at Pakistan Institute of Medical Sciences in November 2018. Ultrasound (USS) was useful in making the diagnosis of a neonatal psoas abscess. He was treated with extraperitoneal drainage and with systemic antibiotics.

Two neonates with Bartter syndrome.

Bartter syndrome is an autosomal recessive disorder caused by gene mutations that involve hypokalaemia, hypochloraemia and metabolic alkalosis along with raised serum renin, hyperaldosteronism and normal blood pressure. We report two cases of neonatal Bartter syndrome. Case 1 was a product of non-consanguineous marriage and mother had unexplained polyhydramnios in pregnancy while case 2 was a product of consanguineous marriage.

In vitro release of interferon-gamma from peripheral blood lymphocytes in cutaneous adverse drug reactions.

Background: Cutaneous drug reactions are common but diagnostically challenging due to phenotypic heterogeneity and simultaneous exposure to multiple drugs. These limitations prompted the development of diagnostic tests.

Aims: To evaluate the performance of an in vitro assay measuring interferon-gamma release from patients' lymphocytes in the presence of causative drugs for the diagnosis of drug reactions.