Subsets of Finns with high HDL to total cholesterol ratio show evidence for linkage to type 2 diabetes on chromosome 6q.

Objectives: The purpose of this study was to examine carefully heterogeneity underlying evidence for linkage to type 2 diabetes (T2DM) on chromosome 6q from two sets of FUSION families.

Methods: Ordered subsets analysis (OSA) was performed on two sets of FUSION families. For OSA results showing significant improvement in evidence for linkage, T2DM-related phenotypes were compared between individuals with T2DM within the subset versus the complement.

Dose-dependent toxicity of a commercially available demineralized bone matrix material.

Study Design: A relative risk assessment was performed to determine the safety of three commercially available Grafton demineralized bone matrix quantities used in athymic rats.

Objective: To evaluate the possible dose-dependent adverse effects of a commercially available demineralized bone matrix containing glycerol.

Summary Of Background Data: Commercially available Grafton demineralized bone matrix contains glycerol.