[Immunological diagnosis of aspergillosis in patients with pulmonary tuberculosis].

The informative value of a number of immunological tests, such as the routine tests of lymphocyte blast cell transformation and indirect hemagglutination, and the original tests of cytotoxic effect and neutrophil damage was studied in diagnosis of aspergillosis. 94 patients with fibro-cavernous tuberculosis and 18 patients with lung aspergillosis along with tuberculosis were examined. It was shown that the tests provided diagnosis of aspergillosis in the tuberculosis patients.

[An experimental model of pulmonary aspergillosis].

The model of experimental chronic pulmonary aspergillosis has been obtained in mice and guinea pigs by the intrapulmonary infection of the animals with the suspension of Aspergillus mycelium and spores in complete Freund's adjuvant. Such method of infection has made it possible to produce chronic local mycotic process. Morphologically, focal inflammatory changes of the lung tissue with the subsequent formation of a multitude of small abscesses in these areas have been observed as characteristic manifestations of aspergillosis.

[A method of determining allergic changes in leukocytes].

The new technique for the detection of hypersensitivity to allergens is based on the fact that after 2 hrs incubation of citrate blood with the allergen the leukocytes are destroyed and K ions leave the cell. Potassium level in the supernatant is measured by flame photometry. This method has been tried in examinations of 81 patients with pulmonary tuberculosis and aspergillosis and 18 healthy donors.