Publications by authors named "I Sevilla"
Article Synopsis
- Prognostic biomarkers are important for understanding sporadic desmoid tumors (DT) due to their unpredictable nature; this study focused on gene expression differences between DTs located in the thoracic versus abdominal wall.
- A retrospective analysis of 197 sporadic DT patients showed significant relationships between relapse-free survival (RFS) and factors like tumor size, location, and specific gene mutations, notably the CTNNB1 T41A and S45F mutations.
- Results suggest that tumors in the abdominal wall have a better prognosis compared to extra-abdominal locations, with distinct gene expression profiles influencing cancer pathways related to their behavior and outcomes.
Nivolumab plus platinum-doublet chemotherapy in treatment-naive patients with advanced grade 3 Neuroendocrine Neoplasms of gastroenteropancreatic or unknown origin: The multicenter phase 2 NICE-NEC trial (GETNE-T1913).
Nat Commun
August 2024
Article Synopsis
- Patients with advanced high-grade digestive neuroendocrine neoplasms (NENs) have a poor prognosis, but adding immune checkpoint inhibition to chemotherapy may improve their survival rates.
- The NICE-NEC trial tested nivolumab alongside carboplatin and etoposide in chemotherapy-naive patients and measured various outcomes, including overall survival and response rates.
- While the primary survival rate goal was not met, the treatment was linked to a median overall survival of 13.9 months and 37.6% of patients surviving more than 2 years, with manageable safety concerns.
Tuberculosis BCG vaccination induced non-specific protective effects in humans led to postulate the concept of trained immunity (TRAIM) as an innate type of immune mechanism that triggered by a pathogen, protects against others. Killed vaccines have been considered not to be effective. However, field efficacy of a commercial vaccine against paratuberculosis, as well as of a recently developed M.
View Article and Find Full Text PDFA humoral diagnostic test outperforms cellular tests in a farm with a latent tuberculosis outbreak caused by a new complex spoligotype that affected sheep but not goats.
Front Vet Sci
January 2024
Tuberculosis (TB) is a disease caused by members of the M. tuberculosis complex (MTC) that affects numerous species. M.
View Article and Find Full Text PDFMycobacterium microti is a member of the Mycobacterium tuberculosis complex that seldom causes disease in livestock and humans. This study evaluated the effects on immunodiagnosis and the pathological findings in goats after experimental exposure by different routes and doses to M. microti.
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