Publications by authors named "I Sauer"
Antibody-dependent cell-mediated cytotoxicity (ADCC) by NK cells is a key mechanism in anti-cancer therapies with monoclonal antibodies, including cetuximab (EGFR-targeting) and avelumab (PDL1-targeting). Fc gamma receptor IIIa (FcγRIIIa) polymorphisms impact ADCC, yet their clinical relevance in NK cell functionality remains debated. We developed two complementary flow cytometry assays: one to predict the FcγRIIIa-V158F polymorphism using a machine learning model, and a 15-color flow cytometry panel to assess antibody-induced NK cell functionality and cancer-immune cell interactions.
View Article and Find Full Text PDFPancreatic ductal adenocarcinoma (PDAC) remains a particularly aggressive disease with few effective treatments. The PDAC tumor immune microenvironment (TIME) is known to be immune suppressive. Oncolytic viruses can increase tumor immunogenicity via immunogenic cell death (ICD).
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- Multimodal two-stage hepatectomy (mTSH) is a surgical approach for patients with bilobar colorectal liver metastases (CRLM) who can't be treated with a single operation due to limited liver function.
- A narrative review of clinical studies shows that interval chemotherapy is used in mTSH and might improve disease control, though only a few studies have specifically reported its effects.
- Current data suggest that interval chemotherapy does not negatively impact liver growth during mTSH or lead to serious complications, but more randomized clinical trials are needed for definitive conclusions.