Pharmacokinetics and antibacterial activity of tiamulin after single and multiple oral administrations in geese.

Tiamulin is an antibiotic approved exclusively in veterinary medicine, active against G-positive bacteria as well as Mycoplasma spp. and Leptospirae spp. The study was aimed to establish its pharmacokinetics and to evaluate drug effects on resistance in cloacal flora in geese.

Robenacoxib pharmacokinetics in sheep following oral, subcutaneous, and intravenous administration.

The aim of this study was to evaluate the pharmacokinetics (PK) of robenacoxib (RX), a COX-2 selective non-steroidal anti-inflammatory drug, in sheep after single subcutaneous (SC), oral (PO), and intravenous (IV) administration. Five healthy female sheep underwent a three-phase parallel study design with a washout period of 4 weeks, in which sheep received a 4 mg/kg SC dose in phase 1, a 4 mg/kg PO administration in phase 2, and a 2 mg/kg IV administration in phase 3. Plasma RX concentrations were measured over a 48 h period for each treatment using HPLC coupled to a UV multiple wavelength detector, and the PK parameters were estimated using a non-compartmental method.

Pharmacokinetics of ivermectin after oral and intravenous administration in Biłgorajska geese ().

Aims: To assess the pharmacokinetic profile of ivermectin in Biłgorajska geese () after single I/V or oral administration, in order to compare these routes of administration and assess oral bioavailability.

Methods: Ten healthy male geese were used in a single-dose, two-phase study with a 3-month washout period between phases. In the first phase, all geese were given 0.

Acetaminophen pharmacokinetics in geese.

Objective: To evaluate the pharmacokinetics of acetaminophen (APAP) after single-dose IV and PO in the goose; to quantify APAP and its main metabolites in goose muscle, heart, lung, liver, and kidney; and to perform a histopathologic evaluation of goose stomach, duodenum, liver, and kidney tissues for potential signs of toxicity.

Animals: 24 geese.

Procedures: Geese were randomly divided into 3 groups (n = 8).