Publications by authors named "I Sardi"
Article Synopsis
- Glioblastoma (GBM) is a significant public health issue partly due to challenges in delivering effective treatments like doxorubicin (DOX) through the blood-brain barrier.
- Two novel DOX glycoconjugates, synthesized with oxime linkages, were shown to maintain the drug's ability to intercalate with DNA, enhancing their effectiveness against GBM cells.
- These glycoconjugates demonstrated improved cytotoxic effects compared to standard DOX in both GBM cell lines and a blood-brain barrier model, suggesting that glucose conjugation could enhance chemotherapy outcomes for GBM patients.
Article Synopsis
- Dabrafenib plus trametinib shows strong effectiveness and manageable side effects for patients with -mutant glioma.
- There is a notable case of a patient with recurrent anaplastic pleomorphic xanthoastrocytoma who had a complete and lasting response to this treatment.
- Continued development of targeted therapies and treatment strategies is expected to enhance personalized care for high-grade glioma patients, ultimately improving their outcomes.
Vascular complications in craniopharyngioma-resected paediatric patients: a single-center experience.
Front Endocrinol (Lausanne)
April 2024
Background: Craniopharyngioma (CP), although slow growing and histologically benign, has high morbidity, mostly related to hypothalamus-pituitary dysfunction and electrolyte imbalance. Increased risk of vascular complications has been described. However, data are still poor, especially in the paediatric population.
View Article and Find Full Text PDFBackground: Texture analysis extracts many quantitative image features, offering a valuable, cost-effective, and non-invasive approach for individual medicine. Furthermore, multimodal machine learning could have a large impact for precision medicine, as texture biomarkers can underlie tissue microstructure. This study aims to investigate imaging-based biomarkers of radio-induced neurotoxicity in pediatric patients with metastatic medulloblastoma, using radiomic and dosiomic analysis.
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