Publications by authors named "I Sancho Val"

Article Synopsis
  • Hydroa vacciniforme (HV) lymphoproliferative disorder is a rare type of NK/T-cell lymphoma primarily found in children, mainly reported in Latin America and parts of Asia.
  • The disorder is categorized under EBV-positive lymphoid proliferations and is classified in the fifth edition of the WHO guidelines for lymphoid neoplasms.
  • A noteworthy case of a 22-year-old woman from Spain illustrates the disease's progression, highlighting the importance of recognizing its uncommon presentation to improve diagnosis and early treatment.
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Background: Adequate lymphadenectomy is an important step in gastrectomy for cancer, with a modified D2 lymphadenectomy being recommended for advanced gastric cancers. When assessing a novel technique for the treatment of gastric cancer, lymphadenectomy should be non-inferior. The aim of this study was to assess completeness of lymphadenectomy and distribution patterns between open total gastrectomy (OTG) and minimally invasive total gastrectomy (MITG) in the era of peri-operative chemotherapy.

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The impact of the glycan distribution on the in vivo function and half-life of monoclonal antibodies has long motivated the genetic engineering of producer cells to achieve structures that enhance efficacy, safety and stability. To facilitate glycoengineering of IgG-producing Chinese hamster ovary cells, we present a rapid protocol that involves the use of RNA interference for the knockdown of genes of interest coupled with capillary gel electrophoresis and laser-induced fluorescence detection (CGE-LIF) for fast, high-throughput glycan analysis. We apply this methodology to the Fut8 gene, responsible for the addition of core fucose, which is a typical target for increasing antibody-dependent cellular cytotoxicity.

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Background: Core outcome sets (COS) should be relevant to key stakeholders and widely applicable and usable. Ideally, they are developed for international use to allow optimal data synthesis from trials. Electronic Delphi surveys are commonly used to facilitate global participation; however, this has limitations.

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