Publications by authors named "I Samija"
Article Synopsis
- In melanomas, BRAF gene mutations are common early events, and this study aimed to compare their frequency in dysplastic nevi (ND) and melanomas in situ (MIS) while examining correlations with clinical factors.
- A total of 175 patients were analyzed, revealing a significant correlation between BRAF mutations and the diagnosis of MIS, while patients with lentigo maligna (LM) had fewer mutations compared to those with ND and MIS.
- The study concluded that while BRAF mutations are essential in ND, they alone are insufficient to trigger melanoma development, enhancing understanding of melanoma's etiology and the role of ND as potential precursors.
Introduction: Diabetic kidney disease (DKD) is one of the major microvascular complications of type 1 diabetes mellitus (T1DM). Some studies suggest that changes of renal tubular components emerge before the glomerular lesions thus introducing the concept of diabetic tubulopathy with urinary neutrophil gelatinase-associated lipocalin (uNGAL) as a potential marker of DKD. This concept was not confirmed in all studies.
View Article and Find Full Text PDFThe early identification of aggressive forms of cancer is of high importance in treating papillary thyroid cancer (PTC). Disease dissemination is a major factor influencing patient survival. Mutation status of oncogene, V600E, is proposed to be an indicator of disease recurrence; however, its influence on PTC dissemination has not been deciphered.
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- A survey was conducted to assess iodine levels and thyroid size in 957 schoolchildren aged 6-12 across various regions in Croatia.
- The median urinary iodine concentration (UIC) was found to be 250.68 µg/L, with significant regional differences, indicating both insufficient (<100 µg/L) and excessive (>300 µg/L) iodine intakes in certain areas.
- Overall, while iodine intake was generally sufficient, with thyroid volumes being normal, some coastal regions showed borderline enlarged thyroids.
The studying of prostate cancer genomics is important for understanding prostate cancer biology, it can provide clinically relevant stratification into subtypes, the development of new prognostic and predictive markers in the context of precision medicine, and the development of new targeted therapies. Recent studies have provided detailed insight into genomics, epigenomics and proteomics of prostate cancer, both primary and metastatic castration-resistant (mCRPC). Many mutations have been discovered, both those that occur early in the carcinogenesis and progression as well as those responsible for the resistance to therapy occurring later under the influence of treatment.
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