Publications by authors named "I Samara"
Atherosclerosis, a term derived from the Greek "athero" (atheroma) and "sclerosis" (hardening), is a long-standing process that leads to the formation of atheromatous plaques in the arterial wall, contributing to the development of atherosclerotic cardiovascular disease. The proliferation and migration of vascular smooth muscle cells (VSMCs) and the switching of their phenotype play a crucial role in the whole process. Retinoic acid (RA), a natural derivative of vitamin A, has been used in the treatment of various inflammatory diseases and cell proliferation disorders.
View Article and Find Full Text PDFAnalytical QbD for the optimization of a multimode HPLC method for the investigation of hydrochlorothiazide, diltiazem and propranolol release from 3D printed formulation.
J Pharm Biomed Anal
September 2024
Since 3D printing technology is an emerging field in pharmaceutical technology, the present study aimed at the development of a mixed-mode liquid chromatographic method for the separation and determination of hydrochlorothiazide, diltiazem, and propranolol to investigate their in-vitro release performance from 3D printed tablets. Due to the unique properties of the mixed-mode stationary phase, the three drugs were separated in less than 8 min under isocratic elution. Method development was accomplished following the Analytical Quality by Design principles and was evaluated using risk assessment and multivariate analysis.
View Article and Find Full Text PDFPrimate faces provide information about a range of variant and invariant traits, including some that are relevant for mate choice. For example, faces of males may convey information about their health or genetic quality through symmetry or facial masculinity. Because perceiving and processing such information may have bearing on the reproductive success of an individual, cognitive systems are expected to be sensitive to facial cues of mate quality.
View Article and Find Full Text PDFArticle Synopsis
- - Drug-coated balloons have been evaluated for safety and effectiveness in treating coronary and peripheral artery disease, with this study focusing on a new everolimus-coated balloon (ECB) in a swine model.
- - Thirty-two swine arteries were tested over 90 days in four groups, comparing different drug dosages of the ECB and other balloon types for their impact on arterial health.
- - Results indicated that the ECB was safe and effective, with one dosage showing the best outcomes, suggesting that the amount of everolimus used could influence how well the balloon works in preventing artery narrowing.
Article Synopsis
- Restenosis and stent thrombosis remain significant issues in stent failure, with current cytostatic drugs contributing to complications like inflammation and arterial cell toxicity.
- Retinoic acid (RA), a vitamin A derivative, shows promise in treating these problems by influencing vascular smooth muscle cell behavior and modulating macrophage activation, supported by various studies.
- Research on RA drug-eluting stents (DES) indicates potential benefits for reducing atherosclerotic plaque development and restenosis, but further studies are needed to ensure their safety and effectiveness in humans.